Advances in Immunology, Vol. 42 by Frank J. Dixon (Ed.)

By Frank J. Dixon (Ed.)

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1985; Yancopoulos and Alt, 1984). The findings indicated that the D most proximal gene family V,, 7183 (see Fig. 1) rearranged with the highest frequency and, in particular, the v h 81X gene rearranged more frequently than any others in this family. The second most frequently rearranged V,, family was the Vh Q52 family which is the next most D proximal v h gene segment family in the BALB/c mice and appears to be inter- CLONOTYPE REPERTOIRE OF B CELL SUBPOPULATIONS 29 mixed with the 7183 v,,family in certain mouse strains.

Nonetheless, since the self-antigen that would be so closely related to NP has not been identified, this also does not constitute formal evidence of a tolerance mechanism shaping the B cell repertoire. , 1980). It would seem that the unusual dominance of A heteroclitic antibodies specific for NP is, in part, the result of the elimination of high-affinity homoclitic K-bearing B cells specific for N P that seems characteristic of antibodies obtained from mice of other heavy chain haplotypes. The distribution of A- and K-bearing antibodies in the pre-B cell pool of Igh" mice, for example, is fairly similar to that of Igh" mice.

1981). In an extensive analysis of PC-specific precursor cells in (CBA/N x BALB/c)F, male mice (Klinman and Stone, 1983), it was found that splenic B cells from these mice have an exceedingly low frequency of cells responsive to PC when conjugated to Hy and, as yet, none of these responses has been Type I anti-PC antibodies. On the other hand, as shown in Table IIB, when the sIg- bone marrow cells of these mice were analyzed, there was an abundant population of PC-specific precursor cells. Indeed, Type I PC-responsive precursor cells, including those of the T15 idiotype, were present in a frequency comparable to that of their normal female littermates.

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