By Jürgen Holtz M.D., Dorothea Darmer Ph.D. (auth.), Heribert Schunkert, G. A. J. Riegger (eds.)
Apoptosis or programmed telephone dying is more and more thought of to be a significant factor within the improvement and development of heart problems. In sufferers with middle failure the activation of apoptosis may end up within the lack of irreplaceable cardiac myocytes selling the scientific process the syndrome. additionally, within the coronary arteries irritation and apoptosis could weaken severe buildings of the vessel wall resulting in plaque rupture and, accordingly, to myocardial infarction. Given those deleterious effects, it kind of feels nearly paradoxical that programmed telephone demise is an energetic strategy that, if initiated lower than physiological conditions, is vital for either coordinated tissue development or destruction of malignant cells.
Apoptosis in Cardiac Biology, written through a staff of across the world well known researchers, supplies a well timed synopsis of uncomplicated mechanisms, mobile and structural objectives and, eventually, medical implications of programmed mobile dying within the middle. The specialist authors of this quantity provide concise overviews on basic and cell-specific facets of programmed telephone loss of life in cardiac myocytes and fibroblasts, in addition to in vascular gentle muscle and endothelial cells. moreover, novel healing suggestions coming up from the exceptional pathophysiological value of cardiac apoptosis are provided.
This entire evaluate of Apoptosis in Cardiac Biology might be of curiosity to either clinicians and easy researchers who're lively within the fields of cardiology and atherosclerosis.
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J. Donahue, S. W. Shenvood, A. L. Gurney, K. J. Hillan, R. L. Cohen, A. D. Goddard, D. Botstein, and A. Ashkenazi. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Nature 396: 699-703, 1998. Pitti, R. , S. A. Marsters, S. Ruppert, C. J. Donahue, A. Moore, and A. Ashkenazi. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 271 : 12687-12690, 1996. Ruoslahti, E. RGD and other recognition sequences for integrins.
Boone, D. Vercammen, K, Vancompernolle, P. Vandenabeele, G. Haegeman, W. Fiers, and J. Grooten. The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region. J B i d Chem 273: 9673-9680, 1998. , S. Geley, R. Hirsch, M. Castedo, P. Marchetti, A. Macho, R. Kofler, and G. Kroemer. Bcl-2 and Bcl-xL antagonize the mitochondria1 dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer Res 57: 62-67, 1997. Degli-Esposti, M.
ScaMidi, F. C. Hischkel, A. Shevchenko, M. Mann, P. H. Krammer, and M. E. Peter. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). Embo J 16: 2794-2804, 1997. Meredith, J. , and M. A. Schwartz. Integrins, adhesion and apoptosis. Trends Cell Biol7: 146150,1997. Mohler, K. , D. S. Torrance, C. A. Smith, R. G. Goodwin, K. E. Stremler, V. F. Fung, H. Madami, and M. B. Widmer. Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists.